Page 40 - _NIPER-G Annual Report 2019-201

Research Area-6

Medicated skin patch to mitigate destructive pulmonary tuberculosis in six districts of
Assam
Quercetin in combination with polyvinylpyrrolidone (PVP) was found to limit the spreading of
necrosis to unaffected tissues in tuberculosis-infected mice. Therefore, we hypothesized that
3D printed medicated skin patch incorporated with a quercetin-PVP combination would
provide an appropriate therapeutic drug concentration with desired sustained release profile.
We fabricated quercetin-PVP extruded-filaments by hot-melt extrusion (HME) technique along
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with Eudragit RSPO and tri-ethyl citrate as a plasticizer and further 3D printed it to make
medicated skin patches using fused deposition modeling (FDM). Patch formulation has been
optimized for several characterization parameters and was further assessed using SEM, DSC,
and XRD studies to confirm the conversion of crystalline quercetin into an amorphous form.
Finally, the pharmacokinetic profile of this optimized patch was studied in rats showed
prolonged Tmax, lowered Cmax, and reduced fluctuations in plasma concentrations. Overall data
confirmed the feasibility of developing 3D printed medicated skin patches to provide plasma
levels for continued 18 days in rats after a single application.

Project Funding Acknowledgement:

This work is funded through Science and Technology (S&T) Division, Assam Science
Technology and Environment (ASTE) Council by Department of Science & Technology
(DST), Government of Assam under the scheme Innovation, Technology Generation,
and Awareness (ITGA)-2019 scheme vide sanction letter no. ASTEC/S&T/1614/8/2018-
19/1151.

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