Page 38 - _NIPER-G Annual Report 2019-201

Research Area-4

Bioengineered bilayer 3D printlets for segregated compartmental delivery of fixed dose
anti-tubercular drug combinations.
This research proposal is sketched to design, fabricate, characterize and perform a detailed
chemical stability and efficacy investigation of novel bioengineered (pH specific) bilayer
(matrix dependent) 3D printlets (printed tablets) for segregated compartmental delivery of RIF
into intestine (to avoid stomach gastric pH induced chemical degradation as alone and FDC)
and INH into stomach (no degradation observed as alone and FDC in stomach gastric pH
conditions) for the desired treatment against TB. The work clearly demonstrates the capability
of 3D printlets by FDM to produce bioenginnered tablets from approved filaments that can
attenuate the current fixed-dose related concerns associated with the TB.

3D Printlets of INH & RIF In vitro dissolution of 3D Printlets

Project Funding Acknowledgement:

Sunrise Project [Ref: NECBH/2019-20/105] under North East Centre for Biological Sciences
and Healthcare Engineering (NECBH) Twinning Outreach Programme hosted by IIT
Guwahati, Assam funded by Department of Biotechnology (DBT), Govt. of India with number
BT/COE/34/SP28408/2018.

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